CLEM Imaging Service Based on ZEISS Crossbeam FIB-SEM and Axio Imager 2

STEMart offers Correlative Light and Electron Microscopy (CLEM) Imaging Services using cutting-edge instruments like the ZEISS Crossbeam FIB-SEM and Axio Imager 2. These systems enable high-resolution imaging that combines the precision of electron microscopy with the functionality of light microscopy. This powerful combination enhances our laboratory’s ability to visualize biological samples in unprecedented detail, aiding in research across a variety of fields.

CLEM technology merges fluorescence microscopy with electron microscopy to study both the structural and functional aspects of a specimen. With the ZEISS Crossbeam FIB-SEM, which integrates focused ion beam technology, and the Axio Imager 2, which delivers advanced light microscopy imaging, STEMart is uniquely equipped to provide a detailed understanding of cellular structures and molecular interactions. This approach is especially useful in disciplines like cell biology, neuroscience, and material sciences.

Leveraging our advanced capabilities in CLEM, STEMart offers a range of services designed to meet the needs of researchers requiring highly precise and correlated imaging solutions. Our comprehensive imaging workflows provide valuable insights into sample structures, giving researchers the ability to make informed conclusions in their studies.

What We Offer

• Correlative Light and Electron Microscopy (CLEM) Service

Enables seamless integration of fluorescent and electron microscopy to reveal both the structural and functional characteristics of biological samples.

• Ultrastructural Mapping

Provides detailed ultrastructural maps of cells and tissues by correlating high-resolution electron microscopy data with light microscopy.

• Fluorescence and Electron Overlay Imaging

Combines fluorescent markers with electron microscopy for a precise understanding of protein localization and structural context.

• 3D Reconstruction of Cellular Architecture

Utilizes FIB-SEM to create three-dimensional models of cells, tissues, and other complex biological samples for advanced structural analysis.

Why Choose Us

• Seamless Integration of Light and Electron Imaging

Our CLEM service bridges the gap between fluorescence and electron microscopy, providing a comprehensive view of sample structures.

• High-Resolution 3D Imaging

With advanced FIB-SEM technology, we deliver nanometer-scale resolution and precise 3D reconstructions of your samples.

• Comprehensive Analysis and Reporting

We provide detailed reports, including correlated data from light and electron microscopy, ensuring that your results are actionable and insightful.

Our Equipment

ZEISS Crossbeam FIB-SEM

This powerful system integrates focused ion beam technology with scanning electron microscopy, allowing for precise 3D reconstructions at high resolutions. It enables in-depth analysis of both biological and material samples, offering unparalleled precision for CLEM workflows.

ZEISS Axio Imager 2

A high-performance light microscope that delivers crisp, detailed fluorescent imaging, essential for the correlative imaging process. Its advanced optics and fluorescence capabilities make it ideal for visualizing complex biological structures.

STEMart provides high-quality advanced microscopy services tailored to meet the specific needs of our clients. Our experienced specialists use advanced equipment and follow strict quality control measures to ensure accurate and reliable results. Contact us to learn more about our advanced microscopy services and how we can help you achieve your research goals.