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Spinal Cord Injury Animal Model (CAT#: STEM-AE-0052-WXH)

Introduction

Spinal cord injury is a disease with a high disability rate, and the number of patients is increasing year by year. Establishing an ideal animal model is the basic premise for studying the disease mechanism.
As a spinal cord injury model, rats also have the following characteristics: good reproducibility; good clinical relevance; high homology with humans; strong repeatability; wide range of adaptation; simple operation; low mortality rate, etc. The spinal cord injury model is usually established by directly cutting the thoracic vertebrae of rats and compressing them with heavy objects.




Applications

• To study the pathogenesis and treatment of spinal cord injury.
• Drug development, drug screening and efficacy research.
• Study the regulation of neuron regeneration after injury.

Procedure

1. Animal Adaptive Feeding.
2. Anesthetizing Mice.
3. Dorsal incision, blunt dissection of muscles, exposing thoracic segments.
4. Cutting the Spinal Cord of Thoracic Segments.
5. Suture.
6. Postoperative care and model evaluation.

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