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Heart Failure Animal Model (CAT#: STEM-AE-0045-WXH)

Introduction

Heart failure is myocardial injury caused by any reason such as myocardial infarction, cardiomyopathy, hemodynamic overload, inflammation, etc., resulting in changes in myocardial structure and function, and finally leading to poor ventricular pumping or filling function. The main clinical manifestations are dyspnea, fatigue and fluid retention.




Applications

• Study the pathogenesis and treatment of heart failure.
• Drug development, drug screening and efficacy research.

Procedure

• Surgical models:banding an aorta or clipping a coronary artery.
• Toxin-induced heart failure.
• Genetic models of heart failure.
• Model Validation: Cardiac Ultrasound, Pathology Detection.

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