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Gene description: CRISPRi-validated cis-regulatory element chr2.7266
Gene type: biological region
This genomic region represents a DNase I hypersensitive site (DHS) that was predicted to be an enhancer by the ENCODE (ENCyclopedia Of DNA Elements) project based on various combinations of H3K27 acetylation and binding of p300, GATA1 and RNA polymerase II in K562 erythroleukemia cells. It was validated as a high-confidence cis-regulatory element for the ASB1 (ankyrin repeat and SOCS box containing 1) gene on chromosome 2 based on multiplex CRISPR/Cas9-mediated perturbation in K562 cells.