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Gene description: CRISPRi-validated cis-regulatory element chr2.7219<br />Gene type: biological region<br />This genomic region represents a DNase I hypersensitive site (DHS) that was predicted to be an enhancer by the ENCODE (ENCyclopedia Of DNA Elements) project based on various combinations of H3K27 acetylation and binding of p300, GATA1 and RNA polymerase II in K562 erythroleukemia cells. It was validated as a high-confidence cis-regulatory element for the UBE2F (ubiquitin conjugating enzyme E2 F (putative)) gene on chromosome 2 based on multiplex CRISPR/Cas9-mediated perturbation in K562 cells.