Analysis of LSM1 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1872-LGZ)

Introduction

Official Full Name: LSM1 homolog, mRNA degradation associated<br />Also known as: CASM; YJL124C<br />This gene encodes a member of the LSm family of RNA-binding proteins. LSm protein forms stable isoforms, specifically binds to the 3'-terminal oligonucleotide (U) region of U6 snRNA, and may play a role in pre-mRNA splicing by mediating the formation of U4/U6 snRNP. Increased expression of this gene may play a role in cellular transformation and progression of several malignancies including lung, mesothelioma and breast cancer. There is an alternatively spliced transcript variant of this gene, and the pseudogene of this gene is located on the short arm of chromosome 9.