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Orthotopic Liver Transplantation Animal Model (CAT#: STEM-AE-0024-WXH)

Introduction

Liver transplantation is the only effective way to treat advanced liver cancer, and you can return to normal life after surgery. Posthepatitic cirrhosis is an indication for liver transplantation. Rat orthotopic liver transplantation animal model is the gold standard in the field of liver transplantation.




Applications

• Study the mechanism and surgical treatment of liver transplantation.
• To study the mechanism of chronic rejection after liver transplantation, preventive measures and application of immunosuppressants.
• Drug development, drug screening and efficacy research.

Procedure

"Two-sleeve" method:
1. Acquisition of Donor Liver.
2. Vascular cuff preparation: the walls of the portal vein and inferior hepatic inferior vena cava are everted, placed on polyethylene tubes and fixed with silk thread.
3. Recipient surgery: remove the liver after anesthetizing the rat, place the donor liver, and anastomose the superior and inferior vena cava.

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