Pharmacodynamic Research and Evaluation

Pharmacodynamics mainly studies the biochemical effects, physiological effects, mechanism of action and the relationship between dose and effect of drugs. The main experimental contents of pharmacodynamic research include in vitro tests (biochemical tests, cell tests, etc.) and in vivo tests (whole animal experiments).

Pharmacodynamic research and evaluation are the prerequisite and basis for the evaluation of tested drugs. Pharmacodynamic research and evaluation are used to determine the therapeutic effect of the test drug, clarify the action characteristics of the test drug, reveal the possible mechanism of action, support the proposed clinical indications, and provide reliable basis for clinical trials of new drugs.

STEMart closely follows industry development and market demand, and is committed to providing timely and convenient pharmacodynamic research and evaluation services for drug research and development to accelerate the progress of customer research projects.

Test Samples

Various new drugs

Service Items

• Pharmacodynamic evaluation of tumor treatment drugs
  • Tumor pharmacodynamic research uses a series of tumor pharmacodynamic evaluation systems such as molecular biology techniques, tumor cell line culture and in vivo nude mouse transplanted tumor models to comprehensively, systematically and in-depth evaluate the preclinical efficacy and anti-tumor mechanism of molecular-targeted drugs at the molecular, cellular and whole animal levels.
• Pharmacodynamic evaluation of cardiovascular system drugs
  • Cardiovascular system research mainly involves screening, preclinical pharmacodynamic evaluation and mechanism research on drugs for treating cardiovascular diseases.
• Pharmacodynamic evaluation of central nervous system drugs
  • This research has established a series of research levels from enzymes, receptors, tissues, whole animal models to model animals for major central nervous system diseases that currently seriously threaten human health in clinical practice, so as to comprehensively and systematically evaluate the preclinical pharmacodynamics and study the mechanism of action of drugs for central nervous system diseases.
• Pharmacodynamic evaluation of endocrine system drugs
  • This research mainly uses type Ⅰ and type Ⅱ diabetes models and rodent transgenic models, and uses glucose tolerance and in vitro glycosidase activity detection methods, blood glucose clamps and molecular biology techniques to comprehensively carry out preclinical efficacy and mechanism research on innovative drugs against diabetes and other metabolic diseases.
• Pharmacodynamic evaluation of digestive system drugs
  • Establish gastric and intestinal ulcer models caused by chemical injury, stress injury and immune injury
  • Conduct experiments to observe gastric and intestinal movements and action potentials in vivo and in vitro
• Pharmacodynamic evaluation of other drugs
  • Pharmacodynamic evaluation of respiratory drugs
  • Pharmacodynamic evaluation of benign prostatic hyperplasia drugs
  • Pharmacodynamic evaluation of drugs for skin diseases

For more information about our pharmacodynamic research and evaluation services, please contact us.