Recombinant Human 4-1BB Ligand Protein, Seafrom (CAT#: STEM-CT-0099-ZJF)

The Recombinant Human 4-1BB Ligand Protein manufactured by Seafrom is suitable for T-cell co-stimulation and immune responses.
Tumor necrosis factor ligand superfamily member 9 (4-1BBL), also known as 4-1BB ligand, CD137L, or TNFSF9, is a cytokine that binds to TNFRSF9. 4-1BBL is a high-affinity ligand for 4-1BB. It induces the proliferation of activated peripheral blood T cells. Additionally, 4-1BBL may play a role in activation-induced cell death (AICD). Furthermore, it might be involved in homotypic interactions between T cells and B cells/macrophages.
Regarding diseases, 4-1BBL is associated with cancer, infectious diseases, and autoimmune disorders.
The lyophilized product can be stored at 2-8°C for 24 months. For reconstitution, you can use sterile water, saline, culture medium, or PBS. After dissolution, divide it into smaller aliquots, store them at -20°C for 6 months or at -80°C for 12 months. The diluted concentration should not be less than 100 μg/mL, and it's essential to avoid repeated freeze-thaw cycles.

Expression Host: Human HEK293 cells
Synonyms: 4-1BB Ligand, TNFSF9, CD137L
Protein Sequence: The DNA sequence encodes human 4-1BB Ligand (NP_003802.1), expressed with an Fc tag at the C-terminus.
Molecular Weight: Recombinant human 4-1BB Ligand protein consists of 467 amino acids, with a predicted theoretical molecular weight of 51 kD.
Purity: >90%, confirmed by SDS-PAGE gel analysis
Endotoxin: <0.1 EU/μg
Biological Activity: Determined by its ability to induce IL-8 secretion from human PBMC cells, with an ED50 ≤ 10 ng/mL.
Purification Method: Chromatographic purification
Appearance: White, loose powder

Optimal Stability
Gmp-Grade Quality
Low Batch-to-Batch Variability
Exceptional Specificity
Robust Bioactivity
Efficient and Reliable Performance

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