Analysis Biophysical Phenotypes of Mantle Cell Lymphoma (MCL) by Suspended Microchannel Resonator (SMR) (CAT#: STEM-PC-0134-CJ)

Introduction

Mantle cell lymphoma (MCL) manifests extensive clinical phenotypic heterogeneity, ranging from indolent to aggressive, rapidly progressive disease. Biophysical phenotypes of cells, such as mass, density and stiffness, are valuable markers of changes in their intrinsic properties and closely associated with cellular states and functions, which have proven useful in elucidating fundamental processes in cell growth and development.

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Principle Applications Procedure Materials Notes Related Products

Principle

The SMR uses the principle that the resonating frequency of an oscillating cantilever (visualize a diving board in motion) is proportional to its mass. The SMR is made up of a cantilever containing a tiny fluidics channel surrounded by a vacuum. When a single cell flows through the channel inside the cantilever, the resonant frequency of the cantilever changes in proportion to the mass of the cell.

Applications

Biochemistry; Biopharmaceuticals; Pharmaceuticals; Biomedical

Procedure

1. Sample preparation.
2. The sample solution flows through the microchannel in the resonant cantilever, and mechanical resonance occurs to obtain data.
3. Analyse the data.

Materials

• Sample: Particle-based APIs (e.g., VLPs, liposomes, polymeric nanoparticles), Virus Particle, Protein Formulations
• Equipment: Suspended Microchannel Resonator (SMR)

Notes

1. The SMR is a microelectromechanical systems (MEMS) device that can weigh individual cells to a precision better than one part in 1,000.
2. Using a suspended microchannel resonator, researchers can measure the relative positions of tiny particles as they flow through a fluidic channel.

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