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Official Full Name: ATPase H+ transporting V1 subunit B2<br />Also known as: DOOD; HO57; VATB; VPP3; Vma2; ZLS2; ATP6B2; ATP6B1B2<br />This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles in eukaryotic cells. V-ATPase-dependent acidification of organelles is essential for intracellular processes such as protein sorting, zymogen activation, receptor-mediated endocytosis, and generation of synaptic vesicle proton gradients. V-ATPase consists of a cytoplasmic V1 domain and a transmembrane V0 domain. The V1 domain consists of 3 A, 3 B and 2 G subunits and C, D, E, F and H subunits. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of the two V1 domain B subunit subtypes and the only B subtype highly expressed in osteoclasts.