Analysis of BCL10 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0115-LGZ)

Introduction

Also known as: CLAP; mE10; CIPER; IMD37; c-E10; CARMEN<br />This gene was translocated in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD) and has been shown to induce apoptosis and activate NF-kappaB. This protein has been reported to interact with other CARD domain-containing proteins, including CARD9, 10, 11, and 14, which are considered upstream regulators of NF-kappaB signaling. The protein was found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to cooperate in the activation of NF-kappaB, and dysregulation of either of them may lead to the same pathological process leading to malignancy. Alternative splicing results in multiple transcript variants.