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Official Full Name: calcium voltage-gated channel auxiliary subunit beta 4<br />Also known as: EA5; EJM; CAB4; EIG9; EJM4; EJM6; CACNLB4<br />This gene encodes a member of the β-subunit family of voltage-dependent calcium channel complex proteins. Calcium ion channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of α-1, α-2/δ, β, and γ subunits in a 1:1:1:1 ratio. Different versions of each of these subunits exist that are either expressed by similar genes or are the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein repression, increasing peak calcium currents, controlling α-1 subunit membrane targeting, and altering the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE), juvenile myoclonic epilepsy (JME), and paroxysmal ataxia type 5.