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B7-H3 (B7 homolog 3 protein), also known as CD276, is an important immune checkpoint molecule of the B7-CD28 family. It is a member of the B7 family identified in the human dendritic cell cDNA library by Chapoval et al. in 2001. B7-H3 mainly exists in membrane protein and soluble form, and soluble B7-H3 (soluble B7-H3, sB7-H3) is cleaved from membrane protein by metalloprotease.