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GADD153 /CHOP (growth arrest and DNA-damage-inducible gene 153 or C/EBP-homologous protein) is a member of the C/EBP transcription factor family. CHOP is a marker gene of ER stress-induced apoptosis, which is involved in ER stress-regulated apoptosis and cells with defective CHOP gene expression significantly reduce ER stress-induced cell death.