Analysis of Contactin-2/TAG-1 (Human) by ELISA (CAT#: STEM-MB-0755-LGZ)

Introduction

Contactin 2 (CNTN2, transiently-expressed axonal glycoprotein, AXT, TAX, TAX1, TAG-1, axonin 1) is a neuronal cell adhesion molecule (CAM) that influences the formation of axon connections in the developing nervous system. Contactin 2 is a member of the immunoglobulin superfamily (IgSF) and contains glycosyl phosphatidylinositol anchors, six immunoglobulin (Ig) -like domains, and four type III fibronectin (FNIII) -like domains. Contactin 2 is expressed mainly on axon cell membranes in nerve fiber bundles during neural development to guide the junction axon without promoting its growth. Contactin 2 binds to NgCAM in the same membrane plane (cis-binding). Contactin 2 heterotropy (Contactin 2/NgCAM and Contactin 2/NrCAM) binding sites were located in the first four Ig domains. The Contactin 2 homology (Contactin 2/Contactin 2) binding site is located in the FNIII domain.