Analysis of DENND2B Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-2223-LGZ)

Introduction

Official Full Name: DENN domain containing 2B<br />Also known as: ST5; HTS1; p126<br />This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified.