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Official Full Name: eukaryotic translation initiation factor 2 alpha kinase 2
Also known as: PKR; PRKR; DYT33; LEUDEN; EIF2AK1; PPP1R83
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation upon binding to dsRNA. The activated form of the encoded protein phosphorylates the translation initiation factor EIF2S1, thereby inhibiting protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against a variety of DNA and RNA viruses.