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Official Full Name: formin 2<br />This gene is a member of the biguanide homolog protein family. The encoded protein is thought to play an important role in the organization and cellular polarity of the actin cytoskeleton. This protein mediates the formation of actin meshwork, positions the spindle during oogenesis, and also regulates the formation of actin filaments in the nucleus. This protein also forms the perinuclear actin/focal adhesion system, which regulates the shape and position of the nucleus during cell migration. Mutations in this gene are associated with infertility and an autosomal recessive form of intellectual disability (MRT47). Another spliced transcript variant has been identified.