Analysis of GDF2 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-2078-LGZ)

Introduction

Official Full Name: growth differentiation factor 2<br />Also known as: BMP9; HHT5; BMP-9<br />This gene encodes a secreted ligand for the tgf-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-β receptors, leading to the recruitment and activation of SMAD family transcription factors, which regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of a disulfide-linked homodimer. This protein regulates cartilage and skeletal development, angiogenesis, and differentiation of cholinergic CNS neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia.