Analysis of IL24 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1068-LGZ)

Introduction

Official Full Name: interleukin 24<br />Also known as: C49A; FISP; MDA7; MOB5; ST16; IL10B<br />This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation of melanoma cells. The protein encoded by this gene can selectively induce apoptosis of various tumor cells. Overexpression of this gene leads to increased expression of multiple genes in the GADD family, which is related to the induction of apoptosis. This gene induces phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38) and heat shock protein 27kDa 1 (HSPB2/HSP27) in melanoma cells but not in normal immortalized melanocytes. Alternative splicing transcript variants encoding different isoforms have been reported.