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Official Full Name: lysine demethylase 5B
Also known as: CT31; PLU1; PUT1; MRT65; PLU-1; JARID1B; PPP1R98; RBP2-H1; RBBP2H1A
This gene encodes a lysine-specific histone demethylase and belongs to the jumonji/ARID domain-containing histone demethylase family. The encoded protein is capable of demethylating trimethyl, dimethyl and monomethyllysine 4 of histone H3. This protein plays a role in the transcriptional repression of certain tumor suppressor genes and is upregulated in some cancer cells. The protein may also play a role in genome stabilization and DNA repair. Alternate splicing results in multiple transcript variants.