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Official Full Name: microsomal glutathione S-transferase 3
Also known as: GST-III
This gene encodes a member of the MAPEG (eicosanoid and glutathione-like metabolic membrane-associated protein) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme that catalyzes the conjugation of leukotriene A4 with reduced glutathione to produce leukotriene C4. This enzyme also exhibits glutathione-dependent peroxidase activity on lipid hydroperoxides.