Analysis of Nectin-4 (Human) by ELISA (CAT#: STEM-MB-1088-LGZ)

Introduction

Nectin-4 (Nectin cell adhesion molecule 4) is a cell adhesion molecule of the Nectin and Nectin-like families, which is highly expressed in normal embryonic and fetal tissues, but very low in healthy adult tissues. Nectin-4 is a type I membrane protein, and the extracellular region of dimeric Nectin-4 consists of three Ig domains of Ig V type and IgC type. The metalloprotease TACE/ADAM-17 degrades the ectodomain to produce soluble Nectin-4. This secreted form is found in patients with breast tumors. Nectin-4 is overexpressed in a variety of tumor cells, and can promote the growth and proliferation of tumor cells. Solid tumors that highly express Nectin-4 include bladder cancer, pancreatic cancer, triple-negative breast cancer, non-small cell lung cancer, gastric cancer, esophageal cancer, ovarian cancer and other cancers.