Analysis of PMS1 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1501-LGZ)

Introduction

Official Full Name: PMS1 homolog 1, mismatch repair system component
Also known as: MLH2; PMSL1; hPMS1; HNPCC3
This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome.