Analysis of PRKCE Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1757-LGZ)

Introduction

Official Full Name: protein kinase C epsilon
Also known as: PKCE; nPKC-epsilon
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that are activated by calcium and the second messenger diacylglycerol. Members of the PKC family phosphorylate a variety of protein targets and participate in a variety of cellular signaling pathways. PKC family members are also major receptors for a class of tumor promoter phobol esters. Each member of the PKC family has a specific expression profile and is thought to play distinct roles in the cell. The protein encoded by this gene is a member of the PKC family. This kinase has been shown to be involved in many different cellular functions such as neuronal channel activation, apoptosis, myocardial ischemic protection, heat shock response, and insulin exocytosis. Mouse knockout studies suggest that this kinase is important for activating lipopolysaccharide (LPS)-mediated signaling in macrophages and may also play a role in the control of anxiety-like behaviors.