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Official Full Name: protein tyrosine phosphatase non-receptor type 22<br />Also known as: LYP; PEP; LYP1; LYP2; PTPN8; PTPN22.5; PTPN22.6<br />This gene encodes a non-receptor class 4 subfamily member of the protein tyrosine phosphatase family. The encoded protein is a lymphocyte-specific intracellular phosphatase associated with the molecular adapter protein CBL, and may be involved in regulating the function of CBL in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternately spliced transcript variants encoding different isoforms have been described.