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Official Full Name: recombination activating gene 2<br />Also known as: Rag-2<br />Achieve multiple functions, including phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and zinc ion binding activity. Involved in V(D)J recombination and exclusion of pre-B-cell alleles. Acts upstream or within several processes, including B cell homeostatic proliferation; lymphocyte differentiation; and positive regulation of organ growth. predicted to be in the nucleoplasm. Expected to be part of the DNA recombinase complex. Expressed in gut; hemolymphoid system; and liver. For the study of Omenn syndrome and severe combined immunodeficiency, autosomal recessive inheritance, T cell negative, B cell negative, NK cell positive. Human ortholog(s) of this gene implied in Omenn syndrome; combined cellular and humoral immune defects with granulomas; severe combined immunodeficiency; cell-positive. Orthologous to human RAG2 (recombination activating 2).