Analysis of RGS1 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0596-LGZ)

Introduction

Official Full Name: regulator of G protein signaling 1<br />Also known as: 1R20; BL34; IER1; IR20; HEL-S-87<br />This gene encodes a member of the G-protein signaling regulator family. The protein is located on the cytoplasmic side of the plasma membrane and contains a conserved 120 amino acid motif called the RGS domain. This protein attenuates the signaling activity of G proteins by binding to activated GTP-bound G α subunits and acting as a GTPase activating protein (GAP), increasing the conversion rate of GTP to GDP. This hydrolysis allows the Gα subunit to associate with the Gβ/γ subunit heterodimer to form an inactive G protein heterotrimer, thereby terminating the signal.