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Saikosaponins are oleanane-based glycosides mostly isolated from the root of the following medicinal plants, Bupleurum spp., Heteromorpha spp., and Scrophularia scorodonia. Saikosaponins have multiple-pharmacological properties which include antiviral, anti-inflammatory, antipyretic, and immunomodulatory effects. Saikosaponin was reported to suppress the production of cytokines (TNF-α), cyclooxygenase (COX-2), inducible nitric oxide synthase (iNOS), and interleukins (IL-6, IL-8, and IL-10) release, which are all involved in the inflammatory process in COVID-19 infection.