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Official Full Name: SET domain bifurcated histone lysine methyltransferase 1<br />Also known as: ESET; KG1T; KMT1E; TDRD21; H3-K9-HMTase4<br />This gene encodes a histone methyltransferase that regulates histone methylation, gene silencing and transcriptional repression. Considering that gene silencing and transcriptional dysfunction may play a role in the pathogenesis of HD, this gene has been identified as a target for HD therapy. Alternative splicing transcript variants of this gene have been described.