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Official Full Name: SMG7 nonsense mediated mRNA decay factor<br />Also known as: EST1C; SGA56M; C1orf16<br />This gene encodes a protein that is critical for nonsense-mediated mRNA decay (NMD); a process in which transcripts with premature stop codons are rapidly degraded by the mRNA decay complex. The mRNA decay complex is partly composed of this protein together with the proteins SMG5 and UPF1. The N-terminal domain of the protein is thought to mediate its association with SMG5 or UPF1, while the C-terminal domain interacts with the mRNA decay complex. Thus, this protein likely couples changes in the phosphorylation state of UPF1 to the degradation of NMD candidate transcripts. Alternative splicing results in multiple transcript variants encoding different isoforms.