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Official Full Name: small proline rich protein 2E<br />This gene encodes members of a small family of proline-rich proteins that cluster on the epidermal differentiation complex on chromosome 1q21. The encoded protein, along with other family members, is an integral part of the keratinocyte envelope formed under the plasma membrane of terminally differentiated stratified squamous epithelium. This envelope acts as a barrier to extracellular and environmental factors. Seven SPRR2 genes (A-G) appear to have been homogenized by gene transformation, while others show greater differences in protein structure.