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TIMPs are endogenous protease inhibitors that combine with matrix metalloproteinases (MMPs) at a 1:1 ratio to form complexes that regulate the activation or function of MMPs. TIMP-1 and TIMP-3 are glycoproteins, whereas TIMP-2 and TIMP-4 do not contain carbohydrates. TIMP-1, TIMP-2 and TIMP-4 are secreted proteins, whereas TIMP-3 is membrane-bound.