Analysis of TLR5 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0706-LGZ)

Introduction

Official Full Name: toll like receptor 5<br />Also known as: SLE1; TIL3; SLEB1; MELIOS<br />This gene encodes a member of the toll-like receptor (TLR) family, which plays an important role in pathogen recognition and activation of the innate immune response. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the major component of flagella and a virulence factor. Activation of this receptor activates nuclear factor NF-κB, which in turn activates a series of inflammation-related target genes. Mutations in this gene are associated with resistance and susceptibility in systemic lupus erythematosus and susceptibility to Legionnaires' disease.