Analysis of TRIM21 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-2184-LGZ)

Introduction

Official Full Name: tripartite motif containing 21<br />Also known as: SSA; RO52; SSA1; RNF81; Ro/SSA<br />This gene encodes a member of a tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a polypeptide and one of four small RNA molecules. RoSSA particles exist both in the cytoplasm and in the nucleus. RoSSA interacts with autoantigens in patients with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing transcript variants of this gene have been described, but the full-length nature of only one has been determined.