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Uromodulin (also known as Tamam-Horsfall glycoprotein or THP) is a urinary glycoprotein of 85 - 95 kDa. It is secreted by the renal tubular epithelium, acts as a binding protein for IL-1, TNF-α, and C1q, activates resting monocytes, and promotes neutrophil phagocytosis. Uromodulin forms high molecular weight oligomers that line the renal tubules.