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Cadherin is a transmembrane glycoprotein critical for calcium-dependent cell-cell adhesion during tissue differentiation. Cadherins aggregate to form foci of homophilic binding units. A key determinant of the strength of cadherin-mediated adhesion may be the paramembrane domain of cadherin VE-cadherin (cadherin 5) is the major cadherin found in endothelial cells and plays an important role in angiogenesis and maintenance of barrier permeability.