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Official Full Name: VHL like
Also known as: VLP; VHLP
Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. VHL inactivation leads to VHL disease and sporadic renal carcinoma. The VHL homologue encoded by this gene lacks one of two key domains required for VHL function. This gene may be involved in the regulation of oxygen homeostasis and neovascularization during placental development. The gene lacks introns and can also be interpreted as a reverse-transcribed pseudogene located at the VHL locus on chromosome 3. However, this protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests that the protein is translated. The same article also states that this protein binds HIFα but cannot recruit the E3 ubiquitin ligase complex, so it acts as a dominant-negative VHL protein and protector of HIFα.