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Serum albumins (SAs) are the major soluble proteins in the circulatory system that acts as a depot and also a carrier for many endogenous and exogenous compounds such as drugs. Bovine SA (BSA) is the most frequently used protein in the drug-protein interaction studies due to its structural homology with human SA (HSA), cheapness, easy availability and considerable stability. It is a large monomeric protein (66 kDa) consisting of about 583 amino acid residues as single chain.<br /><br />Neomycin, an antibiotic, is used to prevent or treat skin infections caused by bacteria. Oral neomycin is used to help lessen the symptoms of hepatic coma, a complication of liver disease. In addition, it may be used with another medicine before any surgery affecting the bowels to help prevent infection during surgery.