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Flavonoids, a class of natural drugs with broad biological activity, exhibit inhibitory effect on α-amylase. Neohesperidin, hesperidin and hesperetin are citrus flavonoids from the flavanones subclass that have anti-inflammatory and antioxidant potential. Neohesperidin, in the form of neohesperidin dihydrochalcone (NHDC), also has dietary properties as a sweetener.<br /><br />α-Amylases are enzymes that catalyze the hydrolysis of the internal α-1,4-glycosidic linkages in starch, converting starch into low-molecular-weight products such as glucose, maltose, and maltotriose units.