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Apolipoprotein A [apo(a)] is a protein carried in HDL ("good") cholesterol. It helps start the process for HDL to remove bad types of cholesterol from your body. In this way, apolipoprotein A can help to lower your risk for cardiovascular disease.<br /><br />Plasminogen is a secreted protein that upon cleavage by urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA) is converted to plasmin, a broad range protease capable of cleaving fibrin and other ECM components. Plasminogen can be cleaved by plasmin at several sites resulting in lysine as the N-terminal amino acid (Lys-plasminogen) and the release of an 8-kDa N-terminal polypeptide. Lys-plasminogen, in the absence of fibrin, is converted to plasmin at a faster rate than Glu-plasminogen.