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TGF-α and the EGF receptor are expressed in many developing and adult tissues, where TGF-α has been implicated in cell migration, growth, and differentiation. The physiological importance of TGF-α is equally pleiotropic, encompassing the organization, homeostasis, protection, and repair of several types of tissues. In addition, Two peptide growth factors which may play important roles in normal wound healing in tissues such as skin, cornea, and gastrointestinal tract are the structurally related peptides epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha).