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Antibodies have been used for decades as agents for the selective binding of target analytes. One common application of antibodies has been their use in immunoaffinity chromatography (IAC) for the purification and isolation of biological compounds. Many IAC methods have been developed for the isolation of antibodies, hormones, peptides, enzymes, viruses and other biologically-relevant materials. The ability of an antibody to recognize a specific target and bind this target with high affinity has traditionally provided immunoaffinity methods with good selectivity and low limits of detection.