BIOshell™ columns provide maximum speed and efficiency for the separation of biomolecules on UHPLC and HPLC systems. Fused-Core® surface porous silica particles have a pore size ranging from 90 to a maximum of 1000 A, and provide excellent separation of glycans and very large proteins (such as monoclonal antibodies (mAb)) or proteins with molecular weights greater than 100 kDa.