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Bone and cartilage are specialized forms of connective tissue that provide structural support for muscles and organs within the human body. Bone is hard, highly vascularized and calcified connective tissue that comprises the skeleton whereas cartilage is soft, flexible, avascular, tissue that serves to absorb shock in the joints between bones, or forms rigid, low-load bearing structures such as within the nose, ear and larynx. The structure and mechanical properties of bone and cartilage are integral to their function, and disruption of these properties is implicated in injury and degenerative conditions such as arthritis and osteoporosis. Earlier detection of changes in the structure and strength of bone and cartilage will facilitate earlier diagnosis, which is key to effective treatment and improved patient outcomes.