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Blood coagulation is a highly regulated process and plays a major role in hemostasis. Upon vessel injury, a concerted action of platelets and plasmatic coagulation stop bleeding and trigger repair of the damaged vessel. Blood coagulation factor XIII (FXIII) is the last factor to be activated in the coagulation cascade and its active form functions as a transglutaminase, which covalently cross-links fibrin polymers and antifibrinolytic proteins such as α2-plasmin inhibitor to fibrin. Because of its function to stabilize fibrin clots, FXIII plays a major role in acute thrombotic events such as myocardial infarction, ischemic stroke, deep vein thrombosis, and pulmonary embolism.