Human Recombinant GRO-beta (CXCL2), STEMCELL Technologies (CAT#: STEM-CT-0878-ZJF)

GRO (growth-regulated oncogene)-beta or CXCL2 is a member of the CXC family, which plays an integral role in recruitment and activation of neutrophils and basophils in response to tissue injury and microbial infection. GRO-beta and GRO-gamma are closely related to GRO-alpha and share 90% and 86% amino acid sequence homology, respectively, with GRO-alpha. Receptor-binding studies have demonstrated that GRO-alpha, -beta, and -gamma signal mainly through G protein-coupled receptors CXCR1 and CXCR2 (Ahuja & Murphy). GRO-beta is expressed in epithelial cells, monocytes, fibroblasts, and melanocytes and is further induced during inflammatory, epithelialization, and angiogenic processes, for example during the wound healing process of human burn wounds (Zaja-Milatovic & Richmond). GRO-beta also stimulates mitogenesis in certain human melanoma cells (Unemori et al.).

Subtype: Cytokines
Alternatives Names: CXCL2, GRO2, Growth regulated protein, Macrophage inflammatory protein-2α, Melanoma growth stimulatory activity, MGSAβ, MIP-2α
Cell Type: Cancer Cells and Cell Lines, Endothelial Cells, Granulocytes and Subsets
Species: Human
Area of Interest: Angiogenic Cell Research, Cancer, Epithelial Cell Biology, Immunology
Molecular Weight: 7.9 kDa
Purity: ≥ 95%

Reliable Consistency: Guarantees uniformity and repeatability in various applications with endotoxin levels below 0.2 EU/μg.
Free of Animal Components: Completely devoid of any animal or human-derived elements.
Broad Selection: Offers a wide range of human, mouse, and rat cytokines available in multiple sizes.

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