In Vivo Pharmacodynamic Evaluation of A2058 Cell Line Based Skin Cancer (CAT#: STEM-AE-0114-LGZ)

Introduction

Skin cancer (abnormal growth of skin cells) is most commonly seen on skin exposed to sunlight. But this common cancer can also appear on skin that is not often exposed to sunlight. There are three main types of skin cancer: basal cell carcinoma, squamous cell carcinoma and melanoma.
Skin cancer begins in the epidermis of the skin. The epidermis is a thin layer that protects the skin cells that the body continually sheds. The epidermis contains three main types of cells:
Squamous cells located just below the outer surface act as the lining of the skin.
Basal cells, which produce new skin cells, are located below squamous cells.
The melanocytes that produce melanin, the pigment that gives skin its normal color, are located under the epidermis. When exposed to sunlight, melanocytes produce more melanin to help protect the deeper layers of your skin.

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Principle Applications Procedure Materials Notes Related Products

Principle

In vivo activity is the gold standard for the evaluation of drug biological activity, and it is the first verification of non-human comprehensive activity. In vivo pharmacodynamic evaluation plays a decisive role in the confirmation of candidate molecules and the screening of clinical target indications, and is an indispensable link in the development of new drugs. We provide a variety of disease animal models including inflammation, immunity, metabolism, etc., to meet the needs of different new drug research and development projects of customers, and accept customized services.
In vivo pharmacodynamic evaluation, as the basic research of new drugs, is carried out on animals. It is to verify the effect of drugs with the comprehensive participation of a number of other factors, and to understand the effect of drugs on a certain part of the body by comparing and analyzing the animal signs, in vitro organs, blood components, histone expression and tissue changes before and after drug administration.

Applications

Skin Cancer

Procedure

1. Disease model construction.
2. Mice dosing.
3. Efficacy monitoring.
4. Biochemical detection of tissue samples.

Materials

• Sample Type: liquid or powder

Notes

Oncology efficacy Service package:
In vivo syngeneic model
In vivo CDX model
In vivo PBMC humanized model
In vivo transgenic mouse model
In vivo orthotropic or Metastasis tumor model

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