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The mouse Pdl1 gene and Ceacam5 gene were replaced by human PD-L1 and CEACAM5 coding sequence in B-hPD-L1 plus/hCEA MC38 cells. Human PD-L1 and CEACAM5 are highly expressed on the surface of B-hPD-L1 plus/hCEA MC38 cells.
B-hPD-L1 plus/hCEA MC38 cells have the capability to establish tumors in vivo and can be used for efficacy studies.
Common name: B-hPD-L1 plus/hCEA MC38
Aliases:
PD-L1: CD274, PDCD1L1
CEA: CD66e, CEACAM5
Organism: Mouse
Tissue types: Colon
Disease: Colon carcinoma
Strain: C57BL/6
Tissue: Colon